RNA Hunter
A fully automated platform for targeting long non-coding RNAs, specifically optimized to address limitations of existing automated services and implement the complete computational drug development pipeline.
RNA Hunter is a cutting-edge platform developed by the FAZENA team, specifically optimized for working with long non-coding RNAs (lncRNAs) and other regulatory RNA molecules. Unlike automated services such as RNA Composer or SimRNA that perform single functions, RNA Hunter implements the entire computational drug development pipeline — from sequence analysis to molecular dynamics — in one integrated, fully automated workflow.
Core Capabilities
Powerful features designed for comprehensive RNA-targeted drug discovery
Binding Site Detection
Identifies possible binding sites based on evolutionary factors and potential energy surface scanning.
Affinity Prediction
Provides initial ligand affinity approximation without requiring tertiary structure knowledge.
Secondary Structure Modeling
Determines secondary structure using various physical and mathematical modeling methods with custom scoring.
Tertiary Structure Building
Constructs tertiary structures and variations using physical, mathematical, and template-based methods.
Flexible Docking
Physics-based scoring function identifies optimal ligand positioning within binding sites.
Molecular Dynamics
100 ns molecular dynamics with automated topology and index file preparation.
How It Works
A streamlined workflow from RNA sequence to therapeutic insights
RNA Sequence Input
Start with your target RNA sequence. The platform processes long non-coding RNAs and regulatory RNA molecules of any length.
Binding Site Identification
Evolutionary analysis and energy surface scanning identify potential binding sites for therapeutic intervention.
Structure Prediction
Advanced algorithms generate secondary and tertiary structure predictions with custom-adaptive scoring systems.
Ligand Docking & Optimization
Flexible docking with physics-based scoring finds optimal ligand positions, followed by molecular dynamics.
Results & Analysis
Comprehensive output including binding affinities, structural models, and dynamic simulation data for drug development.
Key Advantages
What sets RNA Hunter apart from existing solutions
Fully Automated
Complete pipeline automation from sequence input to refined results — no manual intervention required.
No Length Limitations
Unlike other platforms, RNA Hunter handles long non-coding RNAs without size restrictions.
Physics-Based Accuracy
Grounded in physical laws for reliable predictions and meaningful biological insights.
Therapeutic Applications
RNA Hunter can be decisive in drug development for various conditions
Ready to Transform Your RNA Research?
Partner with FAZENA to leverage RNA Hunter for your drug discovery programs. Our platform can accelerate your path from target identification to lead optimization.
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